Bradley T Keller Selected Research

1- (4- (4- (3,3- dibutyl- 7- (dimethylamino)- 2,3,4,5- tetrahydro- 4- hydroxy- 1,1- dioxido- 1- benzothiepin- 5- yl)phenoxy)butyl)- 4- aza- 1- azoniabicyclo(2.2.2)octane

12/2003	SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs.
9/2003	Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435.

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Bradley T Keller Research Topics

Disease

3	Atherosclerosis 09/2005 - 09/2003
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	Alcoholic Fatty Liver 01/2018
1	Cholestasis 02/2016
1	Sclerosing Cholangitis 02/2016
1	Coronary Artery Disease (Coronary Atherosclerosis) 09/2005
1	Vascular System Injuries 01/2005
1	Hyperplasia 01/2005
1	Inflammation (Inflammations) 01/2005
1	Hyperlipidemias (Hyperlipidemia) 11/2003

Drug/Important Bio-Agent (IBA)

2	sodium-bile acid cotransporterIBA 01/2018 - 02/2016
2	CholesterolIBA 01/2018 - 12/2003
2	SodiumIBA 12/2003 - 11/2003
2	bile acid binding proteinsIBA 12/2003 - 11/2003
2	Bile Acids and Salts (Bile Acids)IBA 12/2003 - 09/2003
2	1- (4- (4- (3,3- dibutyl- 7- (dimethylamino)- 2,3,4,5- tetrahydro- 4- hydroxy- 1,1- dioxido- 1- benzothiepin- 5- yl)phenoxy)butyl)- 4- aza- 1- azoniabicyclo(2.2.2)octaneIBA 12/2003 - 09/2003
1	volixibatIBA 01/2018
1	Phospholipids (Phosphatides)FDA LinkGeneric 02/2016
1	LDL Lipoproteins (beta Lipoproteins)IBA 09/2005
1	LDL CholesterolIBA 09/2005
1	Celecoxib (Celebrex)FDA Link 01/2005
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2005
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2005
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2003
1	Apolipoproteins E (ApoE)IBA 09/2003

Therapy/Procedure

1	Stents 01/2005
1	Therapeutics 12/2003